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Surprisingly, extensive down-regulation of miRNAs such as miR-27a, miR-34a, miR-142-5p, and miR-7, involved in cytoprotection against OS and some of them also capable of targeting Nrf2 directly, has been detected in the muscle, CSF, MN progenitors, and blood as well as in post mortem specimens (brain, brain stem, and the spinal cord) of both sALS and fALS patients, unlike healthy controls [258,259,260,261,262]

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Many of the products with extensive characterization are proteins

The National Institutes of Health, which helped fund this fundamental research, had declared a moratorium on recombinant DNA research in warm-blooded animals as scientists evaluated ethical and safety concerns of the new technology